What vancomycin trough target range is typically aimed for in severe infections?

What vancomycin trough target range is typically aimed for in severe infections?

• A. 5-10 mcg/mL
• B. 10-15 mcg/mL
• C. 20-25 mcg/mL
• D. 15-20 mcg/mL

Answer: (D)

In severe infections, you want enough vancomycin exposure to reliably kill the pathogen without causing excess toxicity. The trough level, the lowest concentration just before the next dose, is used to ensure the drug stays above the organism’s MIC throughout the dosing interval. For severe infections, the commonly targeted trough is 15-20 mcg/mL. This range increases the likelihood of achieving an effective AUC/MIC and bacterial kill, while keeping toxicity risk in check. Lower troughs, like 5-10 mcg/mL, are generally too low to treat severe infections effectively. A 10-15 mcg/mL trough may be used for milder infections or less aggressive pathogens, but not for severe disease. Pushing troughs above 20 mcg/mL, such as 20-25, raises the risk of nephrotoxicity without proven additional benefit in most cases.

In severe infections, you want enough vancomycin exposure to reliably kill the pathogen without causing excess toxicity. The trough level, the lowest concentration just before the next dose, is used to ensure the drug stays above the organism’s MIC throughout the dosing interval. For severe infections, the commonly targeted trough is 15-20 mcg/mL. This range increases the likelihood of achieving an effective AUC/MIC and bacterial kill, while keeping toxicity risk in check.

Lower troughs, like 5-10 mcg/mL, are generally too low to treat severe infections effectively. A 10-15 mcg/mL trough may be used for milder infections or less aggressive pathogens, but not for severe disease. Pushing troughs above 20 mcg/mL, such as 20-25, raises the risk of nephrotoxicity without proven additional benefit in most cases.